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Role of lubricin and boundary lubrication in the

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Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptos

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis Kimberly A. Wallera, Ling X. Zhangb, Khaled A. Elsaidc, Braden C. Fleminga,d,e, Matthew L. Warmanf,g, and Gregory D. Jaya,b,h,1 aCenter for Biomedical Engineering and the School of Engineering, Brown University, Providence, RI 02912; bEmergency Medicine Research Laboratory, Department of Emergency Medicine ...

Galectin-3 Binds to Lubricin and Reinforces the .

Effective boundary lubrication by lubricin is dependent upon both its ability to adsorb to articular cartilage 11,12 and the presence of O-linked β(1–3)Gal-GalNAc oligosaccharides 13; however ...

The role of lubricin in normal and pathological joint .

of lubricin, including lubrication and cytoprotection. Lubricin plays an important role in articular joint physiology, and the loss of accumu-lation of lubricin may be a factor in the pathology of osteoarthritis (OA) (Figure 1). Therefore, a recent study8 demonstrated that recombi-nant lubricin has a role in chondro-protection in an animal OA model

The role of lubricin in the mechanical behavior of .

Request PDF on ResearchGate | The role of lubricin in the mechanical behavior of synovial fluid | Synovial fluid is a semidilute hyaluronate (HA) polymer solution, the rheology of which depends on ...

Full-Length Recombinant Human Proteoglycan 4 Interacts .

Abstract. Proteoglycan 4 (PRG4) is a mucin-like glycoprotein present in synovial fluid and at the surface of articular cartilage. The objectives of this study were to (1) assess the articular cartilage surface adsorption and in vitro cartilage boundary lubricating ability of full-length recombinant human PRG4 (rhPRG4), and (2) cartilage boundary lubricating ability of purified rhPRG4, both ...

Regulation of lubricin for functional cartilage tissue .

Structure and functional role of lubricin. Lubricin, a product of the proteoglycan 4 (PRG4) gene, is highly expressed by synoviocytes and superficial zone chondrocytes [].Lubricin, generally known as a proteoglycan, is a glycoprotein that functions as a critical boundary lubricant for articular cartilage and normally isolated from synovial fluid [].

Transcription, Translation, and Function of Lubricin, a .

Lubricin plays a critical role as a boundary lubricant in articulating joints. 1-4 This amphiphilic glycoprotein, which is also called superficial zone protein, ... Boundary lubrication may also be dominant at the cornea–contact lens interface where there is a relative lack of aqueous tear.

The role of lubricin in the ... - PubMed Central (PM

Therefore, lubricin provides a chondroprotective feature to synovial fluid that is distinct from the role lubricin plays at the cartilage surface as a boundary lubricant. Additional MPTM experiments, which involve reintroducing lubricin to HA in the presence of the synovial protein milieu, are needed.

Boundary mode lubrication of articular cartilage by .

Lubrication of cartilage involves a variety of physical and chemical factors, including lubricin, a synovial glycoprotein that has been shown to be a boundary lubricant. It is unclear how lubricin boundary lubricates a wide range of bearings from tissue to artificial surfaces, and if the mechanism is the same for both soluble and bound lubricin.

Lubricin - Brown Universi

provides lubrication but does not prevent wear, enabling a pencil to leave a residue (writing). Lubricin lubricates via the boundary mode which is a regime in the leftward area of the Striebek curve (Márton & Lantos, 2006). This means that boundary lubrication functions independently of synovial fluid viscosity.

Transcription, Translation, and Function of Lubricin, a .

Lubricin plays a critical role as a boundary lubricant in articulating joints. 1-4 This amphiphilic glycoprotein, which is also called superficial zone protein, ... Boundary lubrication may also be dominant at the cornea–contact lens interface where there is a relative lack of aqueous tear.

The role of lubricin in the mechanical behavior of .

Therefore, lubricin provides a chondroprotective feature to synovial fluid that is distinct from the role lubricin plays at the cartilage surface as a boundary lubricant. Additional MPTM experiments, which involve reintroducing lubricin to HA in the presence of the synovial protein milieu, are needed.

The biology of Lubricin: Near frictionless joint motion .

Lubricin is a surface-active mucinous glycoprotein secreted in the synovial joint that plays an important role in cartilage integrity. In healthy joints, lubricin molecules coat the cartilage surface, providing boundary lubrication and preventing cell and protein adhesion.

Role of lubricin and boundary lubrication in the .

Osteoarthritis is a complex disease involving the mechanical breakdown of articular cartilage in the presence of altered joint mechanics and chondrocyte death, but the connection between these factors is not well established. Lubricin, a mucinous glycoprotein encoded by the PRG4 gene, provides boundary lubrication in articular joints. Joint friction is elevated and accompanied by accelerated ...

2. Definition, Function, and Structure of Lubricin and Its .

The boundary lubrication of the surfaces has also been studied, and the role of lubricin and HA (polyelectrolyte) during the initiation and progression and later stages of wear has been investigated in their experiments.

Lubricin: a novel potential biotherapeutic approaches for .

Therefore, a treatment with lubricin which would protect cartilage in vivo would be desirable. This article reviews recent findings with regard to the possible role of lubricin in the progression of OA, and further discusses lubricin as a novel potential biotherapeutic approaches for the treatment of OA.

Friction force microscopy of lubricin and hyaluronic acid .

Lubricin and hyaluronic acid (HA) are two constituents of synovial fluid thought to have a role in boundary lubrication. Boundary lubrication3 is accomplished by lubricants adsorbed or bonded to the apposing bearing surfaces and is operative where surfaces come into contact.4 It is one of the multiple

Anti-Inflammatory Role of Lubricin/Proteoglycan 4 (PRG4 .

Background/Purpose: Lubricin/proteoglycan-4 (PRG4) is a mucinous glycoprotein secreted by synovial fibroblast and superficial zone chondrocyte. PRG4 has a homeostatic multifaceted role in the joint including boundary lubrication, friction lowering of apposed cartilage surfaces and prevention of synovial overgrowth. PRG4 is abundant in the synovial fluid (SF) and its levels are reduced in SF ...